I know this is not going to happen, but Escort/tailing missions are my least favorite missions, followed closely by racing missions, and then forced minigame missions. If they could somehow minimize or eschew these and still tell a quality story, I would be ecstatic.
Failing that, don't bring back Brucie or Mori... unless I am murdering them... with fire. They were my least favorite characters in the entire series to date.
I'm almost done bitching, but the cellphone mechanic from IV needs to be revamped. I heard they were, so this is just a gripe. I don't need someone phone-stalking me like a psycho. That mission where Roman calls and accidentally alerts all the people while you're sneaking was funny though. COUSIN! TEETEES!