I know this is not going to happen, but Escort/tailing missions are my least favorite missions, followed closely by racing missions, and then forced minigame missions. If they could somehow minimize or eschew these and still tell a quality story, I would be ecstatic.
Failing that, don't bring back Brucie or Mori... unless I am murdering them... with fire. They were my least favorite characters in the entire series to date.
I'm almost done bitching, but the cellphone mechanic from IV needs to be revamped. I heard they were, so this is just a gripe. I don't need someone phone-stalking me like a psycho. That mission where Roman calls and accidentally alerts all the people while you're sneaking was funny though. COUSIN! TEETEES!
Never attribute to malice that which can be adequately explained by stupidity.