As it has been pretty much confirmed that V will feature Los Santos as is only fully fledged city, a thought I had would be that considering with III, IV, we have had two additional games/DLCs afterwards, so perhaps we will see Grand Theft Auto V: San Fiero, and Grand Theft Auto V: Las Venturas, which could be available as standalone new maps and storylines for those without large console hard drives, or as installable and downloadable DLC to add to V, to create one Epically large state of San Andreas.
Rockstar has been quoted as saying "...the largest and most ambitious game Rockstar has yet created. A bold new direction in open-world freedom..."
Perhaps this is the bold new direction?
It's just a thought, but how amazing would that be?