The Lead Character..
What do you want, and what do you think it will be?
I'm thinking possibly Asian. In III and SA there were Triads/Yakuza. Maybe this time the story will focus on that element. (Can't remember a Chinese Mafia in VC)
Ideally I'd like a suave clean cut mafia lead character. I think Mafia style is awesome, executions, loan "repayments", etc.
Another possibility is the same route as GTAIII. A no-name character who's not really on anyones side.
Though I'd like the character to speak, tbh.