It would be cool if they featured a post-Katrina New Orleans in some capacity. A goal would be to establish criminal control in a city with a vacuum waiting to be filled. Your competition would be the mob, crack gangs and the MS-13's. Sort of like what's happening there right now. Very contemporary. Of course, Iím somewhat biased since Iím from Loserana.
But I don't think it should be limited to a single city. The natural progression of the game suggests multiple countries for GTA4. GTA has gone from a single city to multiple cities within a state. So it only makes sense that the scope of GTA4 would be much larger, like on a worldwide scale.
Hungry for Stink